Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM52010
Substrate
n/a
Meas. Tech.
FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM52010
Synonyms:
MLS000860923 | N-(1-methoxypropan-2-yl)-7-nitro-1H-indole-2-carboxamide | N-(2-methoxy-1-methyl-ethyl)-7-nitro-1H-indole-2-carboxamide | N-(2-methoxy-1-methylethyl)-7-nitro-1H-indole-2-carboxamide | SMR000459707 | cid_2823665
Type:
Small organic molecule
Emp. Form.:
C13H15N3O4
Mol. Mass.:
277.2759
SMILES:
COCC(C)NC(=O)c1cc2cccc([N+]([O-])=O)c2[nH]1
Structure:
Search PDB for entries with ligand similarity: