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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53423
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.8e+3±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53423
Synonyms:
1,3,5,6-tetrahydroxy-4-(2-methylbut-3-en-2-yl)-2-(3-methylbut-2-enyl)-9-xanthenone | 1,3,5,6-tetrahydroxy-4-(2-methylbut-3-en-2-yl)-2-(3-methylbut-2-enyl)xanthen-9-one | 4-(1,1-dimethylallyl)-1,3,5,6-tetrahydroxy-2-(3-methylbut-2-enyl)xanthone | 4-(2-methylbut-3-en-2-yl)-2-(3-methylbut-2-enyl)-1,3,5,6-tetrakis(oxidanyl)xanthen-9-one | Acylated oxime isatin derivative, 12 | MLS000697632 | SMR000470960 | cid_14412270 | gerontoxanthone I
Type:
Small organic molecule
Emp. Form.:
C23H24O6
Mol. Mass.:
396.4331
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(c2oc3c(-[#8])c(-[#8])ccc3c(=O)c2c1-[#8])C([#6])([#6])[#6]=[#6]
Structure:
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