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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53424
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
3.4e+3±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53424
Synonyms:
(1R,12bR)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-ol | (1R,12bR)-1,2,3,4,6,7,12,12b-octahydropyrido[2,1-a]-carbolin-1-ol | Acylated oxime isatin derivative, 13 | MLS000728593 | SMR000470780 | cid_12868332
Type:
Small organic molecule
Emp. Form.:
C15H18N2O
Mol. Mass.:
242.3162
SMILES:
O[C@@H]1CCCN2CCc3c([nH]c4ccccc34)[C@H]12
Structure:
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