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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53432
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.2e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53432
Synonyms:
4-(4-bromophenyl)-2-[(2-fluorobenzoyl)amino]-3-thenoic acid | 4-(4-bromophenyl)-2-[(2-fluorobenzoyl)amino]-3-thiophenecarboxylic acid | 4-(4-bromophenyl)-2-[(2-fluorobenzoyl)amino]thiophene-3-carboxylic acid | 4-(4-bromophenyl)-2-[(2-fluorophenyl)carbonylamino]thiophene-3-carboxylic acid | 4-(4-bromophenyl)-2-[[(2-fluorophenyl)-oxomethyl]amino]-3-thiophenecarboxylic acid | MLS001180864 | Nonacylated oxime, 21 | SMR000476039 | cid_1806255
Type:
Small organic molecule
Emp. Form.:
C18H11BrFNO3S
Mol. Mass.:
420.252
SMILES:
OC(=O)c1c(NC(=O)c2ccccc2F)scc1-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: