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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53442
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.2e+3±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53442
Synonyms:
(7-chloranyl-3,5-dimethyl-1-benzofuran-2-yl)-(4-oxidanyl-4-phenyl-piperidin-1-yl)methanone | (7-chloro-3,5-dimethyl-1-benzofuran-2-yl)-(4-hydroxy-4-phenylpiperidin-1-yl)methanone | (7-chloro-3,5-dimethyl-2-benzofuranyl)-(4-hydroxy-4-phenyl-1-piperidinyl)methanone | (7-chloro-3,5-dimethyl-benzofuran-2-yl)-(4-hydroxy-4-phenyl-piperidino)methanone | 1-[(7-chloro-3,5-dimethyl-1-benzofuran-2-yl)carbonyl]-4-phenylpiperidin-4-ol | MLS001008702 | O-acyl oxime isatin derivative, 31 | SMR000495189 | cid_23723572
Type:
Small organic molecule
Emp. Form.:
C22H22ClNO3
Mol. Mass.:
383.868
SMILES:
Cc1c(oc2c(Cl)cc(C)cc12)C(=O)N1CCC(O)(CC1)c1ccccc1
Structure:
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