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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53451
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
6.5e+3±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53451
Synonyms:
MLS001163735 | N-(1-adamantyl)-5-nitro-2-furamide | N-(1-adamantyl)-5-nitro-2-furancarboxamide | N-(1-adamantyl)-5-nitro-furan-2-carboxamide | N-(1-adamantyl)-5-nitrofuran-2-carboxamide | N-1-adamantyl-5-nitro-2-furamide | O-acyl oxime isatin derivative, 37 | SMR000498736 | cid_2994355
Type:
Small organic molecule
Emp. Form.:
C15H18N2O4
Mol. Mass.:
290.3144
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)NC(=O)c1ccc(o1)[N+]([O-])=O |TLB:8:6:12:1.11.2,5:3:11:6.9.8,THB:5:6:11:3.12.2|
Structure:
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