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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53456
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.3e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53456
Synonyms:
3-phenyl-4-[(4-propan-2-ylphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione | 4-[(4-Isopropyl-benzylidene)-amino]-5-phenyl-4H-[1,2,4]triazole-3-thiol | 4-[(4-isopropylbenzylidene)amino]-3-phenyl-1H-1,2,4-triazole-5-thione | MLS001205042 | O-acyl oxime isatin derivative, 39 | SMR000513447 | cid_825536
Type:
Small organic molecule
Emp. Form.:
C18H18N4S
Mol. Mass.:
322.427
SMILES:
CC(C)c1ccc(C=Nn2c(n[nH]c2=S)-c2ccccc2)cc1 |w:8.8|
Structure:
Search PDB for entries with ligand similarity: