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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53457
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.4e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53457
Synonyms:
2,4-bis(bromanyl)-6-[(quinolin-8-ylamino)methyl]phenol | 2,4-dibromo-6-[(8-quinolinylamino)methyl]phenol | 2,4-dibromo-6-[(8-quinolylamino)methyl]phenol | 2,4-dibromo-6-[(quinolin-8-ylamino)methyl]phenol | MLS001183429 | O-acyl oxime isatin derivative, 40 | SMR000503121 | cid_1994749
Type:
Small organic molecule
Emp. Form.:
C16H12Br2N2O
Mol. Mass.:
408.087
SMILES:
Oc1c(Br)cc(Br)cc1CNc1cccc2cccnc12
Structure:
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