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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53468
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
9.4e+2±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53468
Synonyms:
2-[3-cyano-4-(2-methoxyphenyl)-6-phenyl-pyridin-2-yl]sulfanylethanoic acid | 2-[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanylacetic acid | 2-[[3-cyano-4-(2-methoxyphenyl)-6-phenyl-2-pyridinyl]thio]acetic acid | 2-[[3-cyano-4-(2-methoxyphenyl)-6-phenyl-2-pyridyl]thio]acetic acid | MLS001203461 | O-acyl oxime isatin derivative, 51 | SMR000516574 | [3-Cyano-4-(2-methoxy-phenyl)-6-phenyl-pyridin-2-ylsulfanyl]-acetic acid | cid_1049793
Type:
Small organic molecule
Emp. Form.:
C21H16N2O3S
Mol. Mass.:
376.428
SMILES:
COc1ccccc1-c1cc(nc(SCC(O)=O)c1C#N)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: