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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53480
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.6e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53480
Synonyms:
1-(3-tert-Butylsulfanyl-[1,2,4]thiadiazol-5-yl)-3-(3-methoxy-phenyl)-urea | 1-(3-tert-butylsulfanyl-1,2,4-thiadiazol-5-yl)-3-(3-methoxyphenyl)urea | 1-[3-(tert-butylthio)-1,2,4-thiadiazol-5-yl]-3-(3-methoxyphenyl)urea | MLS001205986 | O-acyl oxime isatin derivative, 61 | SMR000504723 | cid_24746846
Type:
Small organic molecule
Emp. Form.:
C14H18N4O2S2
Mol. Mass.:
338.448
SMILES:
COc1cccc(NC(=O)Nc2nc(SC(C)(C)C)ns2)c1
Structure:
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