Reaction Details Report a problem with these data
Target
Heat shock cognate 71 kDa protein
Ligand
BDBM31693
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay for Hsc70 Inhibitors
IC50
999000±n/a nM
Citation
 PubChem, PC High Throughput Screening Assay for Hsc70 Inhibitors PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock cognate 71 kDa protein
Synonyms:
HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70887.67
Organism:
Homo sapiens (Human)
Description:
gi_5729877
Residue:
646
Sequence:
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
  
Inhibitor
Name:
BDBM31693
Synonyms:
4-[(2,5-Diethoxy-phenylcarbamoyl)-methyl]-piperazine-1-carboxylic acid ethyl ester | 4-[2-(2,5-diethoxyanilino)-2-keto-ethyl]piperazine-1-carboxylic acid ethyl ester;hydrochloride | 4-[2-(2,5-diethoxyanilino)-2-oxoethyl]-1-piperazinecarboxylic acid ethyl ester;hydrochloride | MLS000076321 | SMR000000824 | cid_6603397 | ethyl 4-[2-(2,5-diethoxyanilino)-2-oxoethyl]piperazine-1-carboxylate;hydrochloride | ethyl 4-[2-[(2,5-diethoxyphenyl)amino]-2-oxidanylidene-ethyl]piperazine-1-carboxylate;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C19H29N3O5
Mol. Mass.:
379.4507
SMILES:
CCOC(=O)N1CCN(CC(=O)Nc2cc(OCC)ccc2OCC)CC1
Structure:
Search PDB for entries with ligand similarity: