Reaction Details Report a problem with these data
Target
Heat shock cognate 71 kDa protein
Ligand
BDBM31710
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay for Hsc70 Inhibitors
IC50
999000±n/a nM
Citation
 PubChem, PC High Throughput Screening Assay for Hsc70 Inhibitors PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock cognate 71 kDa protein
Synonyms:
HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70887.67
Organism:
Homo sapiens (Human)
Description:
gi_5729877
Residue:
646
Sequence:
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
  
Inhibitor
Name:
BDBM31710
Synonyms:
1-(4-chlorophenyl)-3-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)urea | 1-(4-chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)urea | 1-(4-chlorophenyl)-3-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)urea | 1-(4-chlorophenyl)-3-(3-keto-1,5-dimethyl-2-phenyl-3-pyrazolin-4-yl)urea | CHEMBL210298 | MLS000107112 | SMR000111484 | cid_1367800
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O2
Mol. Mass.:
356.806
SMILES:
Cc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
Structure:
Search PDB for entries with ligand similarity: