Reaction Details Report a problem with these data
Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM44073
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
1650±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM44073
Synonyms:
(E)-4-(1,3-benzothiazol-2-yl)-5-[4-(N-methylanilino)-3-nitro-phenyl]pent-4-enoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-[4-(N-methylanilino)-3-nitrophenyl]-4-pentenoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-[4-(N-methylanilino)-3-nitrophenyl]pent-4-enoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-[4-[methyl(phenyl)amino]-3-nitro-phenyl]pent-4-enoic acid | MLS000394839 | SMR000242964 | cid_6141196
Type:
Small organic molecule
Emp. Form.:
C25H21N3O4S
Mol. Mass.:
459.517
SMILES:
CN(c1ccccc1)c1ccc(\C=C(/CCC(O)=O)c2nc3ccccc3s2)cc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: