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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM50743
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
1180±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM50743
Synonyms:
4-[(5E)-4-keto-5-p-anisylidene-2-thioxo-thiazolidin-3-yl]-N-thiazol-2-yl-benzenesulfonamide | 4-[(5E)-5-[(4-methoxyphenyl)methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)benzenesulfonamide | 4-[(5E)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(1,3-thiazol-2-yl)benzenesulfonamide | 4-[(5E)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]-N-(2-thiazolyl)benzenesulfonamide | 4-{5-[(4-methoxyphenyl)methylene]-4-oxo-2-thioxo-1,3-thiazolan-3-yl}-N-(1,3-thiazol-2-yl)benzenesulfonamide | MLS000850782 | SMR000456799 | cid_6364952
Type:
Small organic molecule
Emp. Form.:
C20H15N3O4S4
Mol. Mass.:
489.611
SMILES:
COc1ccc(\C=C2\SC(=S)N(C2=O)c2ccc(cc2)S(=O)(=O)Nc2nccs2)cc1
Structure:
Search PDB for entries with ligand similarity: