Reaction Details
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GTPase KRas [1-37]
Ligand
BDBM54704
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant
EC50
30000±n/a nM
Comments
Extracted from aid = 2043 and tid = 2
Citation
PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant PubChem Bioassay (2009)[AID] More Info.:
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
Inhibitor
Name:
BDBM54704
Synonyms:
UNM-0000306098 | cid_23681059 | sodium;(2S)-2-(6-methoxy-2-naphthalenyl)propanoate | sodium;(2S)-2-(6-methoxy-2-naphthyl)propionate | sodium;(2S)-2-(6-methoxynaphthalen-2-yl)propanoate
Type:
Small organic molecule
Emp. Form.:
C14H13O3
Mol. Mass.:
229.2518
SMILES:
COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
Structure:
