Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-5
Ligand
BDBM400234
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
24.0±n/a nM
Citation
 Saito, T; Higashino, M; Kawaharada, S; Lewis, A; Chambers, MS; Rae, A; Hirst, KL; Hartley, CD Fused imidazole compounds US Patent  US10016439 Publication Date 7/10/2018 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-5
Synonyms:
GABA receptor alpha-5 subunit | GABA(A) receptor subunit alpha-5 (GABAAa5) | GABRA5 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) | Gamma-aminobutyric acid receptor subunit alpha-5 (GABAA)
Type:
Enzyme
Mol. Mass.:
52160.59
Organism:
Homo sapiens (Human)
Description:
P31644
Residue:
462
Sequence:
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
  
Inhibitor
Name:
BDBM400234
Synonyms:
7-((1-(Cyclopropylmethyl)-1H-imidazo[4,5-b]pyrazin-6-yl)amino)-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one | US10016439, 42
Type:
Small organic molecule
Emp. Form.:
C18H18N6O2
Mol. Mass.:
350.3745
SMILES:
CN1C(=O)COc2cc(Nc3cnc4ncn(CC5CC5)c4n3)ccc12
Structure:
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