Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-5
Ligand
BDBM400235
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
42.0±n/a nM
Citation
 Saito, T; Higashino, M; Kawaharada, S; Lewis, A; Chambers, MS; Rae, A; Hirst, KL; Hartley, CD Fused imidazole compounds US Patent  US10016439 Publication Date 7/10/2018 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-5
Synonyms:
GABA receptor alpha-5 subunit | GABA(A) receptor subunit alpha-5 (GABAAa5) | GABRA5 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) | Gamma-aminobutyric acid receptor subunit alpha-5 (GABAA)
Type:
Enzyme
Mol. Mass.:
52160.59
Organism:
Homo sapiens (Human)
Description:
P31644
Residue:
462
Sequence:
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
  
Inhibitor
Name:
BDBM400235
Synonyms:
6-((1-(Cyclopropylmethyl)-1H-imidazo[4,5-b]pyrazin-6-yl)amino)-3-methylbenzo[d]oxazol-2(3H)-one | US10016439, 43
Type:
Small organic molecule
Emp. Form.:
C17H16N6O2
Mol. Mass.:
336.3479
SMILES:
Cn1c2ccc(Nc3cnc4ncn(CC5CC5)c4n3)cc2oc1=O
Structure:
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