Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-5
Ligand
BDBM400236
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
38.0±n/a nM
Citation
 Saito, T; Higashino, M; Kawaharada, S; Lewis, A; Chambers, MS; Rae, A; Hirst, KL; Hartley, CD Fused imidazole compounds US Patent  US10016439 Publication Date 7/10/2018 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-5
Synonyms:
GABA receptor alpha-5 subunit | GABA(A) receptor subunit alpha-5 (GABAAa5) | GABRA5 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) | Gamma-aminobutyric acid receptor subunit alpha-5 (GABAA)
Type:
Enzyme
Mol. Mass.:
52160.59
Organism:
Homo sapiens (Human)
Description:
P31644
Residue:
462
Sequence:
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
  
Inhibitor
Name:
BDBM400236
Synonyms:
7-((9-(Cyclopropylmethyl)-9H-purin-2-yl)amino)-4-(2-methoxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | US10016439, 46
Type:
Small organic molecule
Emp. Form.:
C20H22N6O3
Mol. Mass.:
394.4271
SMILES:
COCCN1C(=O)COc2cc(Nc3ncc4ncn(CC5CC5)c4n3)ccc12
Structure:
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