Reaction Details Report a problem with these data
Target
GTPase KRas [1-37]
Ligand
BDBM54621
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype
Ki
2110±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
  
Inhibitor
Name:
BDBM54621
Synonyms:
1-(2-fluorophenyl)-5-(4-fluorophenyl)-3-(4-methoxyphenyl)-2-pyrazoline | 2-(2-fluorophenyl)-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-3,4-dihydropyrazole | UNM-0000305860 | cid_2883090
Type:
Small organic molecule
Emp. Form.:
C22H18F2N2O
Mol. Mass.:
364.3879
SMILES:
COc1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1ccccc1F |t:9|
Structure:
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