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Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM30741
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B
EC50
15200±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM30741
Synonyms:
2-amino-6-(4-chlorophenyl)-4-(5-methyl-3-furanyl)-3-pyridinecarbonitrile | 2-amino-6-(4-chlorophenyl)-4-(5-methyl-3-furyl)nicotinonitrile | 2-amino-6-(4-chlorophenyl)-4-(5-methylfuran-3-yl)pyridine-3-carbonitrile | 2-azanyl-6-(4-chlorophenyl)-4-(5-methylfuran-3-yl)pyridine-3-carbonitrile | MLS000036685 | SMR000041039 | cid_660120
Type:
Small organic molecule
Emp. Form.:
C17H12ClN3O
Mol. Mass.:
309.75
SMILES:
Cc1cc(co1)-c1cc(nc(N)c1C#N)-c1ccc(Cl)cc1
Structure:
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