Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33138
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1
EC50
25800±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1 PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33138
Synonyms:
MLS000394005 | N-[4-(diethylamino)-3-[(2-methoxyphenyl)sulfamoyl]phenyl]-2-fluoranyl-benzamide | N-[4-(diethylamino)-3-[(2-methoxyphenyl)sulfamoyl]phenyl]-2-fluoro-benzamide | N-[4-(diethylamino)-3-[(2-methoxyphenyl)sulfamoyl]phenyl]-2-fluorobenzamide | SMR000241522 | cid_4010960
Type:
Small organic molecule
Emp. Form.:
C24H26FN3O4S
Mol. Mass.:
471.544
SMILES:
CCN(CC)c1ccc(NC(=O)c2ccccc2F)cc1S(=O)(=O)Nc1ccccc1OC
Structure:
Search PDB for entries with ligand similarity: