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Target
Bcl-2-related protein A1
Ligand
BDBM30741
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1
EC50
4920±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1 PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM30741
Synonyms:
2-amino-6-(4-chlorophenyl)-4-(5-methyl-3-furanyl)-3-pyridinecarbonitrile | 2-amino-6-(4-chlorophenyl)-4-(5-methyl-3-furyl)nicotinonitrile | 2-amino-6-(4-chlorophenyl)-4-(5-methylfuran-3-yl)pyridine-3-carbonitrile | 2-azanyl-6-(4-chlorophenyl)-4-(5-methylfuran-3-yl)pyridine-3-carbonitrile | MLS000036685 | SMR000041039 | cid_660120
Type:
Small organic molecule
Emp. Form.:
C17H12ClN3O
Mol. Mass.:
309.75
SMILES:
Cc1cc(co1)-c1cc(nc(N)c1C#N)-c1ccc(Cl)cc1
Structure:
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