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Target
2'-phosphotransferase
Ligand
BDBM54758
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1).
IC50
142.1±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). PubChem Bioassay (2009)[AID] 
Target
Name:
2'-phosphotransferase
Synonyms:
likely tRNA 2'-phosphotransferase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23631.37
Organism:
Candida albicans SC5314
Description:
gi_68476498
Residue:
207
Sequence:
MPPPDKARRDVLISKALSYLLRHGAEKEKLSIDDQGYVKISDVLSHQRLKSLKTTRDDINRIVQENDKKRFTIKDDMICANQGHSLKAVKNDNLTPMTVDELNQLRIYHGTYRTKLPLIKSSGGLSKMNRNHIHFTCEQYSTCSGIRYNANVLIYINASKCIEHGIVFYKSLNNVILTSGDKDGKLSWEFIDRIVGLDGNEINKEQV
  
Inhibitor
Name:
BDBM54758
Synonyms:
(5Z)-1-(1,1-diketothiolan-3-yl)-5-(2-furfurylidene)-2,6-diketo-4-methyl-nicotinonitrile | (5Z)-1-(1,1-dioxo-3-thiolanyl)-5-(2-furanylmethylidene)-4-methyl-2,6-dioxo-3-pyridinecarbonitrile | (5Z)-1-(1,1-dioxothiolan-3-yl)-5-(furan-2-ylmethylidene)-4-methyl-2,6-dioxopyridine-3-carbonitrile | (5Z)-1-[1,1-bis(oxidanylidene)thiolan-3-yl]-5-(furan-2-ylmethylidene)-4-methyl-2,6-bis(oxidanylidene)pyridine-3-carbonitrile | 1-(1,1-Dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-5-[1-furan-2-yl-meth-(Z)-ylidene]-4-methyl-2,6-dioxo- 1,2,5,6-tetrahydro-pyridine-3-carbonitrile | MLS000763132 | SMR000439547 | cid_5923363
Type:
Small organic molecule
Emp. Form.:
C16H14N2O5S
Mol. Mass.:
346.358
SMILES:
CC1=C(C#N)C(=O)N(C2CCS(=O)(=O)C2)C(=O)\C1=C/c1ccco1 |c:1|
Structure:
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