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Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM268478
Substrate
n/a
Meas. Tech.
Nuclear receptor ROR-gamma
Temperature
298.15±n/a K
EC50
14.0±n/a nM
Comments
extracted
Citation
 Fauber, B; Gobbi, A Keto-imidazopyridine derivatives as RORc modulators US Patent  US9550771 Publication Date 1/24/2017 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM268478
Synonyms:
2-hydroxy-4-[3-[2-methyl-6- (trifluoromethyl)benzoyl]-5,6,7,8- tetrahydroimidazo[1,5-a]pyridin- 1-yl]benzoic acid | US9550771, Example 77
Type:
Small organic molecule
Emp. Form.:
C23H19F3N2O4
Mol. Mass.:
444.4032
SMILES:
Cc1cccc(c1C(=O)c1nc(c2CCCCn12)-c1ccc(C(O)=O)c(O)c1)C(F)(F)F
Structure:
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