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Target
M18 aspartyl aminopeptidase
Ligand
BDBM47616
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).
IC50
1506±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). PubChem Bioassay (2009)[AID] 
Target
Name:
M18 aspartyl aminopeptidase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
65642.43
Organism:
Plasmodium falciparum 3D7
Description:
gi_23505220
Residue:
570
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLDKNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITNDINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAAVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
  
Inhibitor
Name:
BDBM47616
Synonyms:
2-amino-3-[(4-hydroxyphenyl)diazenyl]-7-methylpyrazolo[1,5-a]pyrimidin-5(4H)-one | 2-amino-3-[N'-(4-ketocyclohexa-2,5-dien-1-ylidene)hydrazino]-7-methyl-1H-pyrazolo[1,5-a]pyrimidin-5-one | 2-amino-7-methyl-3-[2-(4-oxo-1-cyclohexa-2,5-dienylidene)hydrazinyl]-1H-pyrazolo[1,5-a]pyrimidin-5-one | 2-amino-7-methyl-3-[2-(4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-1H-pyrazolo[1,5-a]pyrimidin-5-one | 2-azanyl-7-methyl-3-[2-(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)hydrazinyl]-1H-pyrazolo[1,5-a]pyrimidin-5-one | MLS000705177 | SMR000230990 | cid_5705988
Type:
Small organic molecule
Emp. Form.:
C13H12N6O2
Mol. Mass.:
284.2734
SMILES:
Cc1cc(=O)[nH]c2c(N=Nc3ccc(O)cc3)c(N)nn12 |w:8.7|
Structure:
Search PDB for entries with ligand similarity: