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Target
Procathepsin L
Ligand
BDBM55133
Substrate
n/a
Meas. Tech.
QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM55133
Synonyms:
MLS000391635 | N-(2-bromanyl-4-nitro-phenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanamide;hydrochloride | N-(2-bromo-4-nitro-phenyl)-2-(1H-1,2,4-triazol-5-ylthio)acetamide;hydrochloride | N-(2-bromo-4-nitrophenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide;hydrochloride | N-(2-bromo-4-nitrophenyl)-2-(1H-1,2,4-triazol-5-ylthio)acetamide;hydrochloride | SMR000260670 | cid_15945326
Type:
Small organic molecule
Emp. Form.:
C10H8BrN5O3S
Mol. Mass.:
358.171
SMILES:
[O-][N+](=O)c1ccc(NC(=O)CSc2nnc[nH]2)c(Br)c1
Structure:
Search PDB for entries with ligand similarity: