Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM57749
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
27551±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM57749
Synonyms:
2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(5-nitro-2-furanyl)-3-oxopropanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(5-nitrofuran-2-yl)-3-oxidanylidene-propanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(5-nitrofuran-2-yl)-3-oxopropanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-keto-3-(5-nitro-2-furyl)propionitrile | MLS000418549 | SMR000265016 | cid_5668947
Type:
Small organic molecule
Emp. Form.:
C14H8N4O4
Mol. Mass.:
296.2377
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)[C-](C#N)c1[nH]c2ccccc2[nH+]1
Structure:
Search PDB for entries with ligand similarity: