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Target
Large T antigen
Ligand
BDBM58977
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits
EC50
>50000±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits PubChem Bioassay (2009)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM58977
Synonyms:
5-tert-Butyl-2-phenyl-2H-pyrazole-3-carboxylic acid (4-hydroxy-benzylidene)-hydrazide | 5-tert-butyl-N'-[(4-ketocyclohexa-2,5-dien-1-ylidene)methyl]-2-phenyl-pyrazole-3-carbohydrazide | 5-tert-butyl-N'-[(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)methyl]-2-phenyl-pyrazole-3-carbohydrazide | 5-tert-butyl-N'-[(4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-2-phenyl-3-pyrazolecarbohydrazide | 5-tert-butyl-N'-[(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-phenylpyrazole-3-carbohydrazide | MLS000555119 | SMR000171552 | cid_5758009
Type:
Small organic molecule
Emp. Form.:
C21H22N4O2
Mol. Mass.:
362.425
SMILES:
CC(C)(C)c1cc(C(=O)NN=Cc2ccc(O)cc2)n(n1)-c1ccccc1 |w:10.9|
Structure:
Search PDB for entries with ligand similarity: