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Target
Large T antigen
Ligand
BDBM59040
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits
EC50
3950±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits PubChem Bioassay (2009)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM59040
Synonyms:
Bis (1-epiallohelenalinyl) malonate | MLS000728545 | SMR000445658 | cid_16745512
Type:
Small organic molecule
Emp. Form.:
C33H36O10
Mol. Mass.:
592.6329
SMILES:
[H][C@@]12C=CC(=O)[C@@]1(C)[C@@]1([H])OC(=O)C(=C)[C@]1([H])[C@@H](C[C@H]2C)OC(=O)CC(=O)O[C@@H]1C[C@@H](C)[C@@]2([H])C=CC(=O)[C@@]2(C)[C@@]2([H])OC(=O)C(=C)[C@]12[H] |c:2,37|
Structure:
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