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Target
Large T antigen
Ligand
BDBM59082
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits
EC50
11340±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits PubChem Bioassay (2009)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM59082
Synonyms:
2-[2,5-diketo-4-methyl-4-(p-tolyl)imidazolidin-1-yl]-N-[4-(2-pyridyl)thiazol-2-yl]acetamide | 2-[4-methyl-4-(4-methylphenyl)-2,5-bis(oxidanylidene)imidazolidin-1-yl]-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)ethanamide | 2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]-N-[4-(2-pyridinyl)-2-thiazolyl]acetamide | 2-[4-methyl-4-(4-methylphenyl)-2,5-dioxoimidazolidin-1-yl]-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)acetamide | MLS001159763 | SMR000716052 | cid_24982028
Type:
Small organic molecule
Emp. Form.:
C21H19N5O3S
Mol. Mass.:
421.472
SMILES:
Cc1ccc(cc1)C1(C)NC(=O)N(CC(=O)Nc2nc(cs2)-c2ccccn2)C1=O
Structure:
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