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Target
Kappa-type opioid receptor
Ligand
BDBM60211
Substrate
n/a
Meas. Tech.
uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay
IC50
8520±n/a nM
Citation
 PubChem, PC uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay (2009)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM60211
Synonyms:
4-(1-pyrrolidinylsulfonyl)-N-(8-quinolinyl)benzenesulfonamide | 4-(Pyrrolidine-1-sulfonyl)-N-quinolin-8-yl-benzenesulfonamide | 4-pyrrolidin-1-ylsulfonyl-N-quinolin-8-yl-benzenesulfonamide | 4-pyrrolidin-1-ylsulfonyl-N-quinolin-8-ylbenzenesulfonamide | 4-pyrrolidinosulfonyl-N-(8-quinolyl)benzenesulfonamide | MLS000034735 | SMR000003835 | cid_644442
Type:
Small organic molecule
Emp. Form.:
C19H19N3O4S2
Mol. Mass.:
417.502
SMILES:
O=S(=O)(Nc1cccc2cccnc12)c1ccc(cc1)S(=O)(=O)N1CCCC1
Structure:
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