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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61318
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
20460±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61318
Synonyms:
MLS000807104 | N-(2-chlorophenyl)-2-[[2-(2-furfurylcarbamoylamino)-2-keto-ethyl]-methyl-amino]acetamide | N-(2-chlorophenyl)-2-[[2-(furan-2-ylmethylcarbamoylamino)-2-oxidanylidene-ethyl]-methyl-amino]ethanamide | N-(2-chlorophenyl)-2-[[2-(furan-2-ylmethylcarbamoylamino)-2-oxoethyl]-methylamino]acetamide | N-(2-chlorophenyl)-2-[[2-[[(2-furanylmethylamino)-oxomethyl]amino]-2-oxoethyl]-methylamino]acetamide | SMR000376203 | cid_2698464
Type:
Small organic molecule
Emp. Form.:
C17H19ClN4O4
Mol. Mass.:
378.81
SMILES:
CN(CC(=O)NC(=O)NCc1ccco1)CC(=O)Nc1ccccc1Cl
Structure:
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