Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61375
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
25930±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61375
Synonyms:
MLS001121478 | N-[5-[methyl(o-tolyl)sulfamoyl]-1,3,4-thiadiazol-2-yl]-2-furamide | N-[5-[methyl-(2-methylphenyl)sulfamoyl]-1,3,4-thiadiazol-2-yl]-2-furancarboxamide | N-[5-[methyl-(2-methylphenyl)sulfamoyl]-1,3,4-thiadiazol-2-yl]furan-2-carboxamide | SMR000626603 | cid_16017390
Type:
Small organic molecule
Emp. Form.:
C15H14N4O4S2
Mol. Mass.:
378.426
SMILES:
CN(c1ccccc1C)S(=O)(=O)c1nnc(NC(=O)c2ccco2)s1
Structure:
Search PDB for entries with ligand similarity: