Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61313
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
2480±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61313
Synonyms:
10-hydroxy-11-(4-methyl-4-morpholin-4-iumyl)undecanoic acid methyl ester;iodide | 10-hydroxy-11-(4-methylmorpholin-4-ium-4-yl)undecanoic acid methyl ester;iodide | 4-(2-Hydroxy-10-methoxycarbonyl-decyl)-4-methyl-morpholin-4-ium | MLS001030075 | SMR000427263 | cid_16682274 | methyl 10-hydroxy-11-(4-methylmorpholin-4-ium-4-yl)undecanoate;iodide | methyl 11-(4-methylmorpholin-4-ium-4-yl)-10-oxidanyl-undecanoate;iodide
Type:
Small organic molecule
Emp. Form.:
C17H34NO4
Mol. Mass.:
316.4556
SMILES:
COC(=O)CCCCCCCCC(O)C[N+]1(C)CCOCC1
Structure:
Search PDB for entries with ligand similarity: