Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61317
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
4075±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61317
Synonyms:
3-[[anilino(oxo)methyl]-[(2,4,6-trimethyl-1-cyclohex-3-enyl)methyl]amino]propyl-trimethylammonium;iodide | MLS000333849 | SMR000440173 | Trimethyl-{3-[3-phenyl-1-(2,4,6-trimethyl-cyclohex-3-enylmethyl)-ureido]-propyl}-ammonium | cid_2859481 | trimethyl-[3-[phenylcarbamoyl-[(2,4,6-trimethylcyclohex-3-en-1-yl)methyl]amino]propyl]ammonium;iodide | trimethyl-[3-[phenylcarbamoyl-[(2,4,6-trimethylcyclohex-3-en-1-yl)methyl]amino]propyl]azanium;iodide
Type:
Small organic molecule
Emp. Form.:
C23H38N3O
Mol. Mass.:
372.5668
SMILES:
CC1CC(C)=CC(C)C1CN(CCC[N+](C)(C)C)C(=O)Nc1ccccc1 |c:4|
Structure:
Search PDB for entries with ligand similarity: