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Target
G-protein coupled receptor 35
Ligand
BDBM61605
Substrate
n/a
Meas. Tech.
Image-Based HTS for Selective Antagonists of GPR35
IC50
529.7123±n/a nM
Citation
 PubChem, PC Image-Based HTS for Selective Antagonists of GPR35 PubChem Bioassay (2010)[AID] 
Target
Name:
G-protein coupled receptor 35
Synonyms:
G protein-coupled receptor 35 | GPR35 | GPR35_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34085.57
Organism:
Homo sapiens (Human)
Description:
gi_33695097
Residue:
309
Sequence:
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
  
Inhibitor
Name:
BDBM61605
Synonyms:
(E)-1-[4-[4-[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]phenyl]-3-(dimethylamino)prop-2-en-1-one | (E)-1-[4-[4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]phenyl]-3-(dimethylamino)-2-propen-1-one | (E)-1-[4-[4-[3-chloro-5-(trifluoromethyl)-2-pyridyl]piperazino]phenyl]-3-(dimethylamino)prop-2-en-1-one | (E)-1-[4-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]phenyl]-3-(dimethylamino)prop-2-en-1-one | 1-(4-{4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}phenyl)-3-(dimethylamino)-2-propen-1-one | MLS000539863 | SMR000125321 | cid_1477048
Type:
Small organic molecule
Emp. Form.:
C21H22ClF3N4O
Mol. Mass.:
438.874
SMILES:
CN(C)\C=C\C(=O)c1ccc(cc1)N1CCN(CC1)c1ncc(cc1Cl)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: