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Target
Bcl-2-like protein 1
Ligand
BDBM51308
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL).
IC50
108803±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM51308
Synonyms:
4-(2-furanyl)-6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carbonitrile | 4-(2-furyl)-2-keto-6-(p-tolyl)-1H-pyridine-3-carbonitrile | 4-(2-furyl)-6-(4-methylphenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile | 4-(furan-2-yl)-6-(4-methylphenyl)-2-oxidanylidene-1H-pyridine-3-carbonitrile | 4-(furan-2-yl)-6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carbonitrile | MLS000850476 | SMR000456494 | cid_368866
Type:
Small organic molecule
Emp. Form.:
C17H12N2O2
Mol. Mass.:
276.2894
SMILES:
Cc1ccc(cc1)-c1cc(-c2ccco2)c(C#N)c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: