Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM62642
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM62642
Synonyms:
2-(1-methyltetrazol-5-yl)sulfanyl-N-(4-phenoxyphenyl)propanamide | 2-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanyl]-N-(4-phenoxyphenyl)propanamide | 2-[(1-methyl-5-tetrazolyl)thio]-N-(4-phenoxyphenyl)propanamide | 2-[(1-methyltetrazol-5-yl)thio]-N-(4-phenoxyphenyl)propionamide | MLS000058605 | SMR000068156 | cid_2999605
Type:
Small organic molecule
Emp. Form.:
C17H17N5O2S
Mol. Mass.:
355.414
SMILES:
CC(Sc1nnnn1C)C(=O)Nc1ccc(Oc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: