Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM37484
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM37484
Synonyms:
1-cyclopentyl-5-oxidanylidene-N-[3-[4-(phenylmethyl)piperidin-1-yl]propyl]pyrrolidine-3-carboxamide | 1-cyclopentyl-5-oxo-N-[3-[4-(phenylmethyl)-1-piperidinyl]propyl]-3-pyrrolidinecarboxamide | MLS000120149 | N-[3-(4-benzylpiperidin-1-yl)propyl]-1-cyclopentyl-5-oxopyrrolidine-3-carboxamide | N-[3-(4-benzylpiperidino)propyl]-1-cyclopentyl-5-keto-pyrrolidine-3-carboxamide | SMR000097066 | cid_5309860
Type:
Small organic molecule
Emp. Form.:
C25H37N3O2
Mol. Mass.:
411.5802
SMILES:
O=C(NCCCN1CCC(Cc2ccccc2)CC1)C1CN(C2CCCC2)C(=O)C1
Structure:
Search PDB for entries with ligand similarity: