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Target
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Ligand
BDBM64792
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 1 (PP1)
IC50
57600±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 1 (PP1) PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Synonyms:
PP-1A | PP1A_HUMAN | PPP1A | PPP1CA | Serine/threonine protein phosphatase PP1-alpha catalytic subunit | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | protein phosphatase 1, catalytic subunit, alpha isoform 3
Type:
PROTEIN
Mol. Mass.:
37510.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197827
Residue:
330
Sequence:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
  
Inhibitor
Name:
BDBM64792
Synonyms:
4-O-[3-cyclopropyl-2-(4-hydroxybutyl)-7-methyl-6,8-dioxoisoquinolin-7-yl] 1-O-methyl butanedioate | CMLD003552 | MLS000438594 | O4-[3-cyclopropyl-7-methyl-2-(4-oxidanylbutyl)-6,8-bis(oxidanylidene)isoquinolin-7-yl] O1-methyl butanedioate | SMR000452646 | butanedioic acid O4-[3-cyclopropyl-2-(4-hydroxybutyl)-7-methyl-6,8-dioxo-7-isoquinolinyl] ester O1-methyl ester | cid_16745608 | succinic acid O4-[3-cyclopropyl-2-(4-hydroxybutyl)-6,8-diketo-7-methyl-7-isoquinolyl] ester O1-methyl ester
Type:
Small organic molecule
Emp. Form.:
C22H27NO7
Mol. Mass.:
417.4523
SMILES:
COC(=O)CCC(=O)OC1(C)C(=O)C=C2C=C(C3CC3)N(CCCCO)C=C2C1=O |c:27,t:13,15|
Structure:
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