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Target
Tumor necrosis factor
Ligand
BDBM55564
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
20000±0 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM55564
Synonyms:
2-(3-methylphenyl)-1H-naphtho[2,3-g]indazole-3,6,11-trione | 2-(m-tolyl)-1H-naphth[2,3-g]indazole-3,6,11-trione | 2-m-Tolyl-1,2-dihydro-naphtho[2,3-g]indazole-3,6,11-trione | MLS000554621 | SMR000171820 | cid_3126078
Type:
Small organic molecule
Emp. Form.:
C22H14N2O3
Mol. Mass.:
354.3582
SMILES:
Cc1cccc(c1)-n1[nH]c2c3C(=O)c4ccccc4C(=O)c3ccc2c1=O
Structure:
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