Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54344
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
1826±257 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54344
Synonyms:
(6-amino-5-nitro-pyrimidin-4-yl)-(4-methylbenzyl)amine | 4-N-[(4-methylphenyl)methyl]-5-nitropyrimidine-4,6-diamine | MLS000683236 | N4-[(4-methylphenyl)methyl]-5-nitro-pyrimidine-4,6-diamine | N4-[(4-methylphenyl)methyl]-5-nitropyrimidine-4,6-diamine | SMR000323057 | cid_3259083
Type:
Small organic molecule
Emp. Form.:
C12H13N5O2
Mol. Mass.:
259.2639
SMILES:
Cc1ccc(CNc2ncnc(N)c2[N+]([O-])=O)cc1
Structure:
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