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Target
Tumor necrosis factor
Ligand
BDBM54370
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
3219±266 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54370
Synonyms:
2-chloranyl-N-(1-ethanoylindol-3-yl)-N-(4-methylphenyl)ethanamide | MLS000332636 | N-(1-Acetyl-1H-indol-3-yl)-2-chloro-N-p-tolyl-acetamide | N-(1-acetyl-3-indolyl)-2-chloro-N-(4-methylphenyl)acetamide | N-(1-acetylindol-3-yl)-2-chloro-N-(4-methylphenyl)acetamide | N-(1-acetylindol-3-yl)-2-chloro-N-(p-tolyl)acetamide | SMR000435967 | cid_900031
Type:
Small organic molecule
Emp. Form.:
C19H17ClN2O2
Mol. Mass.:
340.803
SMILES:
CC(=O)n1cc(N(C(=O)CCl)c2ccc(C)cc2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: