Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54453
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
2672.5±190 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54453
Synonyms:
1-phenylethyl(thieno[2,3-d]pyrimidin-4-yl)amine | MLS001176808 | N-(1-phenylethyl)-4-thieno[2,3-d]pyrimidinamine | N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine | SMR000596445 | cid_3991439
Type:
Small organic molecule
Emp. Form.:
C14H13N3S
Mol. Mass.:
255.338
SMILES:
CC(Nc1ncnc2sccc12)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: