Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM65901
Substrate
n/a
Meas. Tech.
Mode of action assay-Automated electrophysiology assay of compounds that potentiate KCNQ2 potassium channel
EC50
4190±720 nM
Citation
 PubChem, PC Mode of action assay-Automated electrophysiology assay of compounds that potentiate KCNQ2 potassium channel PubChem Bioassay (2010)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM65901
Synonyms:
5-chloranyl-2-[(2-fluorophenyl)methylsulfonyl]-N-(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide | 5-chloro-2-(2-fluorobenzyl)sulfonyl-N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]pyrimidine-4-carboxamide | 5-chloro-2-[(2-fluorophenyl)methylsulfonyl]-N-(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide | 5-chloro-2-[(2-fluorophenyl)methylsulfonyl]-N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]-4-pyrimidinecarboxamide | MLS001116197 | SMR000625784 | cid_16446305
Type:
Small organic molecule
Emp. Form.:
C15H11ClFN5O3S3
Mol. Mass.:
459.926
SMILES:
CSc1nnc(NC(=O)c2nc(ncc2Cl)S(=O)(=O)Cc2ccccc2F)s1
Structure:
Search PDB for entries with ligand similarity: