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Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM65922
Substrate
n/a
Meas. Tech.
Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel
EC50
2220±1030 nM
Citation
 PubChem, PC Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel PubChem Bioassay (2011)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM65922
Synonyms:
1-(2,4-dichlorobenzyl)-3-phenyl-urea | 1-[(2,4-dichlorophenyl)methyl]-3-phenyl-urea | 1-[(2,4-dichlorophenyl)methyl]-3-phenylurea | MLS001178478 | N-(2,4-dichlorobenzyl)-N'-phenylurea | SMR000476871 | cid_886930
Type:
Small organic molecule
Emp. Form.:
C14H12Cl2N2O
Mol. Mass.:
295.164
SMILES:
Clc1ccc(CNC(=O)Nc2ccccc2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: