Reaction Details Report a problem with these data
Target
Ammonium transporter MEP2
Ligand
BDBM66010
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically MEP2 based on MLPCN hits
EC50
6846±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically MEP2 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Ammonium transporter MEP2
Synonyms:
AMT2 | MEP2 | MEP2_YEAST
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53401.07
Organism:
Saccharomyces cerevisiae
Description:
gi_1302091
Residue:
499
Sequence:
MSYNFTGTPTGEGTGGNSLTTDLNTQFDLANMGWIGVASAGVWIMVPGIGLLYSGLSRKKHALSLLWASMMASAVCIFQWFFWGYSLAFSHNTRGNGFIGTLEFFGFRNVLGAPSSVSSLPDILFAVYQGMFAAVTGALMLGGACERARLFPMMVFLFLWMTIVYCPIACWVWNAEGWLVKLGSLDYAGGLCVHLTSGHGGLVYALILGKRNDPVTRKGMPKYKPHSVTSVVLGTVFLWFGWMFFNGGSAGNATIRAWYSIMSTNLAAACGGLTWMVIDYFRCGRKWTTVGLCSGIIAGLVGITPAAGFVPIWSAVVIGVVTGAGCNLAVDLKSLLRIDDGLDCYSIHGVGGCIGSVLTGIFAADYVNATAGSYISPIDGGWINHHYKQVGYQLAGICAALAWTVTVTSILLLTMNAIPFLKLRLSADEEELGTDAAQIGEFTYEESTAYIPEPIRSKTSAQMPPPHENIDDKIVGNTDAEKNSTPSDASSTKNTDHIV
  
Inhibitor
Name:
BDBM66010
Synonyms:
4-N-(3-fluorophenyl)-2-N-methyl-5-nitropyrimidine-2,4,6-triamine | MLS000332706 | N'-(3-Fluoro-phenyl)-N-methyl-5-nitro-pyrimidine-2,4,6-triamine | N4-(3-fluorophenyl)-N2-methyl-5-nitro-pyrimidine-2,4,6-triamine | N4-(3-fluorophenyl)-N2-methyl-5-nitropyrimidine-2,4,6-triamine | SMR000436035 | [4-amino-6-(3-fluoroanilino)-5-nitro-pyrimidin-2-yl]-methyl-amine | cid_3528206
Type:
Small organic molecule
Emp. Form.:
C11H11FN6O2
Mol. Mass.:
278.2424
SMILES:
CNc1nc(N)c(c(Nc2cccc(F)c2)n1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: