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Target
Vacuolar aminopeptidase 1
Ligand
BDBM66008
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
4086±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Saccharomyces cerevisiae
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM66008
Synonyms:
(E)-1-(5-Bromo-2-hydroxy-phenyl)-3-pyridin-2-yl-propenone | (E)-1-(5-bromanyl-2-oxidanyl-phenyl)-3-pyridin-2-yl-prop-2-en-1-one | (E)-1-(5-bromo-2-hydroxy-phenyl)-3-(2-pyridyl)prop-2-en-1-one | (E)-1-(5-bromo-2-hydroxyphenyl)-3-(2-pyridinyl)-2-propen-1-one | (E)-1-(5-bromo-2-hydroxyphenyl)-3-pyridin-2-ylprop-2-en-1-one | MLS000776955 | SMR000413352 | cid_6049359
Type:
Small organic molecule
Emp. Form.:
C14H10BrNO2
Mol. Mass.:
304.139
SMILES:
Oc1ccc(Br)cc1C(=O)\C=C\c1ccccn1
Structure:
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