Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM54371
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
2530±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM54371
Synonyms:
2-Hydroxy-benzoic acid [1-quinolin-8-yl-meth-(E)-ylidene]-hydrazide | 2-hydroxy-N-(8-quinolinylmethylideneamino)benzamide | 2-hydroxy-N-(8-quinolylmethyleneamino)benzamide | 2-hydroxy-N-(quinolin-8-ylmethylideneamino)benzamide | 2-oxidanyl-N-(quinolin-8-ylmethylideneamino)benzamide | MLS000779089 | SMR000415800 | cid_4209216
Type:
Small organic molecule
Emp. Form.:
C17H13N3O2
Mol. Mass.:
291.304
SMILES:
Oc1ccccc1C(=O)NN=Cc1cccc2cccnc12
Structure:
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