Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67299
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
3980±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67299
Synonyms:
(7-Chloro-4-nitro-benzo[1,2,5]oxadiazol-5-yl)-pyridin-2-yl-amine | (7-chloro-4-nitro-benzofurazan-5-yl)-(2-pyridyl)amine | 7-chloranyl-4-nitro-N-pyridin-2-yl-2,1,3-benzoxadiazol-5-amine | 7-chloro-4-nitro-N-(2-pyridinyl)-2,1,3-benzoxadiazol-5-amine | 7-chloro-4-nitro-N-pyridin-2-yl-2,1,3-benzoxadiazol-5-amine | MLS000333446 | SMR000436767 | cid_2772102
Type:
Small organic molecule
Emp. Form.:
C11H6ClN5O3
Mol. Mass.:
291.65
SMILES:
[O-][N+](=O)c1c(Nc2ccccn2)cc(Cl)c2nonc12
Structure:
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